NutriClean^® 7-Day Cleansing System*

• Helps maintain digestive health
• Promotes liver and colon health
• Supports overall health by helping to maintain normal cholesterol levels, helping to maintain normal blood glucose levels and promoting immune health
• Assists with healthy nutrient absorption
• Helps to cleanse and detoxify the liver

TLS^® Nutrition Shake – Chocolate & Vanilla

• 19 grams of protein and 10 grams of fiber per serving
• Optimal balance of carbohydrates, fats and protein
• Great taste
• High in calcium
• No trans fats

TLS CORE; Fat & Carb Inhibitor*

• Helps promote weight loss
• Supports leptin sensitivity, which may help to manage hunger and stimulate lipolysis
• May help to reduce fat stores in the body
• Promotes reduction in body mass index (BMI)
• Inhibits the amylase enzyme and slows the absorption of carbohydrates into the bloodstream
• Helps maintain normal blood sugar levels

Isotonix^® Daily Essential Packets

Isotonix OPC-3^® *

• Promotes cardiovascular health PLUS:
  • Helps maintain healthy cholesterol & blood glucose levels
  • Helps maintain healthy circulation by strengthening capillaries, arteries and veins
  • Promotes healthy blood vessel dilation
• Promotes joint health

Isotonix^® Multivitamin*

• Contains 100% or more of the Recommended Daily Value of essentialvitamins & minerals
• Supports a strong immune system
• Supplements dietary deficiencies

Isotonix^® Calcium Plus*

• Supports skeletal health
• Promotes normal regulation of enzyme & hormone production
• Supports cardiovascular health

Isotonix Activated B-Complex*

• Increases energy & fuels optimal energy production
• Promotes a healthy nervous system, bone marrow & intestinal tract
• Promotes cardiovascular health
• Maintains healthy levels of serotonin, thereby decreasing stress & improving mood

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

1. Who should use the TLS^® 30-Day Jump-Start Kit?
   Anyone who is looking for an easy-to-follow, cost-effective, all-inclusive kit that promotes optimal body composition and addresses the essentials of effective weight loss. Whether you need to tone up, lose weight or want to jumpstart a longer weight loss journey — the 30-Day Jump-Start Kit is for you.*
   
   
2. How do I use the 30-Day Jump-Start Kit?
   During Phase 1, take the NutriClean^® Cleansing System, Isotonix^® Daily Essentials Packets and TLS® CORE Fat & Carb Inhibitor supplements. In Phase 2, use the TLS^® Nutrition Shakes as snacks and continue taking the Isotonix Daily Essentials Packets and TLS CORE Fat & Carb Inhibitor supplements. For best results, use in conjunction with the 30-Day Jump-Start Guide. Follow the nutritional directive outlined in the Guide and take supplements as directed.
   
   
3. How does TLS^® CORE Fat & Carb Inhibitor support weight management?
   TLS CORE Fat & Carb Inhibitor enhances your weight loss efforts with its active ingredient, white kidney bean extract. White kidney bean extract inhibits the enzymes that normally breakdown starch into glucose within the small intestine. White kidney bean extract uses a calculated approach to affect the utilization of carbohydrates once they enter the body, helping to inhibit the absorption of carbohydrates. This gives you an advantage by minimizing the effects of surplus carbohydrates that are waiting to be converted into fat within the body.*
   
   TLS CORE Fat & Carb Inhibitor also contains Bitter melon (Momordica charantia) fruit extract, which is cultivated throughout South America as a food and for its health properties. Bitter melon is known for its health properties and its role in maintaining normal blood sugar levels. Charatin, one of several constituents in better melon, is believed to act as its primary mechanism to helping the body maintain normal blood sugar levels.* 
   
   
4. How do I use NutriClean^® 7-Day Cleansing System?
   You need to be sure that you are able to fully commit to the system for seven consecutive days. In the mornings, two hours after your first meal of the day, take two Release tablets (from the blister pack.) Also, drink 8 fluid ounces of the NutriClean Advanced Fiber Powder Drink Mix (mixing as directed). Throughout the day, be sure to drink plenty of water and other fluids (a minimum of 32 ounces, optimally 64 ounces per day). At bedtime, take the entire contents of one daily packet, which includes two Release tablets and two HepatoCleanse capsules. Repeat this cycle for seven consecutive days, taking the tablets/fiber/capsules at the same time each day.
   
   
5. How do TLS^® Nutrition Shakes assist with weight loss?
   TLS Nutrition Shakes provide a source of quality protein to promote a feeling of fullness, helping you stay away from junk foods.
   
   
6. Why do I need to take a multivitamin?
   A good quality vitamin and mineral supplement creates a sound micronutrient foundation to accompany a balanced diet. Vitamins and minerals help to support a healthy immune system, promote the conversion of food into energy, support a healthy cardiovascular system, support strong bones, promote mental clarity, help maintain normal metabolic functioning, promote healthy growth and repair of tissues, help maintain normal blood pressure and help maintain water and electrolyte balance in the body.*
   
   
7. Why are Isotonix^® supplements better than standard supplements?
   Isotonix formulas are more effective than standard supplement formulas because they offer efficient delivery of vitamins, minerals and nutrients into the bloodstream. The stomach has very little work to do because the pH and tonicity are carefully designed to allow the stomach to quickly release all the nutrients into the small intestine.*
   
   
8. Do I have to exercise to see results? 
   In Phase 1 exercise is not recommended, but during Phase 2 exercise is essential. As with most weight loss supplements, these products are designed to be taken in conjunction with a healthy diet and exercise. The steady loss of body fat combined with a steady increase in muscle tissue, achieved through proper nutrition and exercise, is the proven method for achieving weight loss and fitness goals.

NutriClean^® 7-Day Cleansing System

• Agarwal K et al. Feasibility studies to control acute diarrhea in children by feeding fermented milk preparations Actimel and Indian Dahi. European Journal of Clinical Nutrition. 56(Supplement 4): S56-S59, 2002.
• Arunachalam K et al. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). European Journal of Clinical Nutrition. 54(3):263-7, 2000.
  
• Brighenti F et al. Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. European Journal of Clinical Nutrition. 53(9):726-733, 1999.
• Cashman K. A prebiotic substance persistently enhances intestinal calcium absorption and increases bone mineralization in young adolescents. Nutrition Reviews. 64: 189-96, 2006.
• Cetinkaya, A., et al. N-Acetylcysteine Ameliorates Methotrexate-Induced Oxidative Liver Damage in Rats. Medical Science Monitor. 12(8): 274-278, 2006.
• Cummings J et al. A study of fructo oligosaccharides in the prevention of travellers' diarrhoea. Alimentary Pharmacology and Therapeutics. 15:1139-1145, 2001.
• Cunningham-Rundles S et al. Probiotics and immune response. American Journal of Gastroenterology. 95(1 Suppl):S22-5, 2000.
• Davidson M et al. Effects of dietary insulin in serum lipids in men and women with hypercholesterolaemia. Nutrition Research 3:503-17, 1998.
• De Roos N et al. Effects of probiotic bacteria on diarrhea, lipid metabolism, and carcinogenesis: a review of papers published between 1988 and 1998. American Journal of Clinical Nutrition. 71(2):405-11, 2000.
• Evans M et al. Glutamine prevents cytokine-induced apoptosis in human colonic epithelial cells. Journal of Nutrition. 133(10):3065-3071, 2003.
• Fernandes C et al. Control of diarrhea by lactobacilli. Journal of Applied Nutrition. 40:32-43, 1988.
• Flickinger E. Glucose-based oligosaccharides exhibit different in vitro fermentation patterns and affect in vivo apparent nutrient digestibility and microbial populations in dogs. Journal of Nutrition 130:1267-73, 2000.
• Furukawa S et al. Glutamine-enhanced bacterial killing by neutrophils from postoperative patients. Nutrition. 13(10):863-869, 1997.
• Gibson G et al. Selective stimulation of bifidobacteria in the human colony by oligofructose and inulin. Gastroenterology. 108:975-982, 1995.
• Gibson G. Dietary modulation of the human gut microflora using the prebiotics oligofructose and inulin. Journal of Nutrition 129: 1438S-1441S, 1999.
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• Kren, V. and Walterova, D. Silybin and Silymarin--New Effects and Applications. Biomedical papers of the Medical Faculty of the University Palack

TLS^® Nutrition Shake

• Blomstrand E, et al, Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr 136, (1 Suppl): 269S-73S (2006)
• Burke, G, et al, The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength. Int J Sport Nutr Exerc Metab 11, 3:349-64 (2001)
• Meunier PJ. Calcium, vitamin D and vitamin K in the prevention of fractures due to osteoporosis. Osteoporos Int. 1999;9 Suppl 2:S48-52.
• Miller ER 3rd, Appel LJ, Levander OA, Levine DM. The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors. J Cardiovasc Risk. 1997 Feb;4(1):19-24.
• Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
• Nishi Y. Anemia and zinc deficiency in the athlete. J Am Coll Nutr. 1996 Aug;15(4):323-4.
• Ohtani M, et al, Amino acid mixture improves training efficiency in athletes. J Nutr 136, 2:538S-543S (2006)
• Rennie MJ, et al, Branched-chain amino acids as fuel and anabolic signals in human muscle. J Nutr 136, (1 Suppl): 264S-8S (2006)
• Shimomura Y, et al, Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. J Nutr 134, (6 Suppl): 1583S-1587S (2004)
• Tipton KD, et al, Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise. Med Sci Sports Exerc 36, 12:2073-81 (2004)
• Tokunaga K and Matsuoka A, Effects of a [FOSHU] which contains indigestible dextrin as an effective ingredient on glucose and lipid metabolism," J Japanese Diabetes Society , 42:61-65, 1999.)
• Wargovich MJ, Eng VWS, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett. 1984; 23:253-258.
• Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:141-155.
• West KP Jr, Pokhrel RP, Katz J, et al. Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet. 1991; 338:67-71.
• West SG, Light KC, Hinderliter AL, et al. Potassium supplementation induces beneficial cardiovascular changes during rest and stress in salt sensitive individuals. Health Psychol. 1999; 18:229-240.
• Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical triglyceride trials. JAMA. 1997; 277:1624-1632.
• Wolf RL, Cauley JA, Baker CE, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000; 72:466-471.
• Zemel MB, Shi H, Greer B, et al. Regulation of adiposity by dietary calcium. FASEB J. 2000; 14:1132-1138.

TLS^® CORE Fat & Carb Inhibitor

• Anderson, R., et al. Chromium supplementation of human subjects: effects on glucose, insulin, and lipid variables. Metabolism. 32(9): 894-899, 1983.
• Anderson, R. Effects of chromium on body composition and weight loss. Nutrition Reviews. 56(9): 266-270, 1998.
• Blundell, J., et al. Regulation of appetite: role of leptin in signaling systems for drive and satiety. International Journal of Obesity. 25(Supplement 1): 529-534, 2001.
• Bray, G. and York, D. Clinical review 90: Leptin and clinical medicine: a new piece in the puzzle of obesity. Journal of Clinical Endocrinology and Metabolism. 82(9):2771-6, 1997.
• Cefalu, W. and Hu, F. Role of chromium in human health and in diabetes. Diabetes Care. 27: 2741- 2751, 2004.
• Celleno, L., et al. A dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. International Journal of Medical Sciences. 4(1):45-52, 2007.
• Di Pierro, F., et al. GreenSelect^® Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Alternative Medicine Review. 14:154-160, 2009.
• Flegal, K., et al. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 303(3):235-241, 2010.
• French, S. Effects of dietary fat and carbohydrate on appetite vary depending upon site and structure. British Journal of Nutrition. 93(Supplement 1): S23-S26, 2004.
• Friedman, J. The function of leptin in nutrition, weight, and physiology. Nutrition Reviews. 60(10 Pt 2):S1-14; discussion S68-84, 85-7, 2002. Review.
• Kaats, G., et al. A randomized, double-masked, placebo-controlled study of the effects of chromium picolinate supplementation on body composition: a replication and extension of a previous study. Current Therapeutic Research. 59(6): 379-387, 1998.
• Kuate, D., et al. The use of LeptiCore in reducing fat gain and managing weight loss in patients with metabolic syndrome. Lipids in Health and Disease. 9: 1-7, 2010.
• Martin, J., et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. 29(8): 1826-1832, 2006.
• Obiro, W., et al. The nutraceutical role of Phaseolus vulgaris alpha-amylase inhibitor. British Journal of Nutrition. 100: 1-12, 2008.
• Pittler, M. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. American Journal of Clinical Nutrition. 79(4): 529-536, 2004.
• Preuss, H. and Anderson, R. Chromium update: examining recent literature 1997-1998. Current Opinion in Clinical Nutrition and Metabolic Care. 1(6): 509-512, 1998.
• Preuss H. Bean amylase inhibitor and other carbohydrate absorption blockers: effects on diabesity and general health. Journal of the American College of Nutrition. 28(3):266-76, 2009.
• Qi, Y., et al. Adiponectin acts in the brain to decrease body weight. Nature Medicine. 10(5):524-9, 2004.
• Rabinovitz, H., et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. International Journal of Vitamin and Nutrition Research. 74(3):178-82, 2004.
• Sinha, M. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. Journal of Clinical Investigation. 98(6):1277-82, 1996.
• Sparti, A., et al. Effect of diets high or low in unavailable and slowly digestible carbohydrates on the pattern of 24-h substrate oxidation and feeling of hunger in humans. The American Journal of Clinical Nutrition. 73: 1462-1468, 2000.
• TalYeh, G., et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 26(4): 1277-1294, 2003.
• Udani J., et al. Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Alternative Medicine Review. 9(1):63-9, 2004.
• Udani, J and Singh B. Blocking carbohydrate absorption and weight loss: a clinical trial using a proprietary fractionated white bean extract. Alternative Therapies in Health and Medicine. 13(4):32-7, 2007.
• Wang, M., et al. Fat storage in adipocytes requires inactivation of leptin’s paracrine activity: implications for treatment of human obesity. Proceedings National Academy of Sciences USA. 102(50):18011-6, 2005.
• Zeman, M., et al. Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women. Neuro Endocrinology Letters. 30(3):387-95, 2009.

Isotonix^® Daily Essentials Packets

Isotonix OPC-3^®:

• Cesarone, M., et al. Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavanoid Formula OPC-3OPC-3. Journal Angiology 59: 408-414, 2008.
  
• Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
  
• Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
• Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
• Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
• Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
• Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
• Gulati, O. Pycnogenol^® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
• Hosseini, S., et al. Pycnogenol^® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
• Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol^®. European Bulletin of Drug Research 7: 30-32, 1999.
• Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
• Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
• Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
• Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
• Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
• Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
• Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
• Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
• Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
• Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
• Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol^®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
• Rohdewald, P. Pycnogenol^®. In "Flavonoids in Health and Disease". Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
• Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
• Roseff, S., et al. Improvement of sperm quality by Pycnogenol^®. European Bulletin of Drug Research 7: 33-6, 1999.
• Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
• Schönlau, F., et al. Pycnogenol^® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
• Schönlau, F., et al. The cosmeceutical Pycnogenol^®. J Appl Cosmetology 20: 241-6, 2002.
• Segger, D. and Schönlau, F. Supplementation with Evelle^® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
• Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
• Sharma, S., et al. Pycnogenol^® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
• Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol^®. Phytotherapy Research 15: 219-23, 2001.
• Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
• Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
  
• Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
• Watson, R. Pycnogenol^® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
• Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
• Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
• Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.
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• Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002.
• Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.
• Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.
• Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991.
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• Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998.
• Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neuroscience 19: 8114-21, 1999.
• Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects. Br J Nutr 88: 389-98, 2002.
• Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993.
• Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.
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• Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139-43, 1995.
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• Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999.
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• Tomco, A, et al. Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995.
• Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.
• Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.
• Lau B et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
• Choi YH, Yan GH. Pycnogenol^® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
• Sharma SC, Sharma S, Gulati OP. Pycnogenol^® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
• Hosseini S, Pishnamazi S, Sadrzadeh MH, Farid F, Farid R, Watson RR. Pycnogenol^® in the management of asthma. J Med Food 4: 201-209, 2001.

Isotonix^® Multivitamin

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• Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. N Engl J Med 1999;340:101-107.
• Baron JA, Tosteson TD, Wargovich MJ, et al. Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 1995;87:1303-1307.
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• Baxter GF, Sumeray MS, Walker JM. Infant size and magnesium: insights into LIMIT-2 and ISIS-4 from experimental studies. Lancet. 1996; 348:1424-1426.
• Behl C. Vitamin E and other antioxidants in neuroprotection. Int J Vitam Nutr Res. 1999 May;69(3):213-9. 4. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer. 2000 Feb 15;88(4):737-48.
• Bellamy MC, Gedney JA. Unrecognized iron deficiency in critical illness. Lancet. 1998; 352:1903.
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Isotonix^® Activated B-Complex

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• Duthie, S. J., et al. Homocysteine, B vitamin status, and cognitive function in the elderly. American Journal of Clinical Nutrition. 75(5):908-913, 2002.
• Friso, S., et al. Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk. Am J Clin Nutr. 79(6):992-998, 2004.
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• Heseker, H., et al. Psychological disorders as early symptoms of a mild-to-moderate vitamin deficiency. Ann N Y Acad Sci. 669:352-357, 1992.
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• Kelly, G. S. Nutritional and botanical interventions to assist with the adaptation to stress. Alternative Medicine Review.4(4):249-265, 1999.
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• Riggs, K. M., et al. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. American Journal of Clinical Nutrition. 63(3):306-314, 1996.
• Van den Berg M., et al. Combined vitamin B-6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia. Journal Vascular Surgery. 20(6):933-940, 1994.
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Isotonix^® Calcium Plus:

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• Beattie JH, Peace HS. The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. Br J Nutr. 1993 May;69(3):871-84.
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• Christin Marandino, Vegetarian Times, August 1998
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• Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
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