Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

Sensoril^® Trim/Ashwagandha root extract: 450 mg
Ashwagandha has antioxidant, anti-anxiety, and sedative properties. It has been proven to act as an adaptogen by helping to inhibit occasional fatigue, boost energy, promote emotional well-being and counteract the negative effects of stress. Preliminary evidence suggests ashwagandha helps to regulate stress-induced levels of dopamine receptors in the corpus striatum of the brain. It also appears to promote normal levels of plasma corticosterone, blood urea nitrogen and blood lactic acid. Acting as an adaptogen, ashwagandha reduces stress placed on adrenals to perform, thereby helping to decrease the possibility of adrenal fatigue. Though the exact mechanisms by which ashwagandha works are unknown, one hypothesis is that it functions by way of GABA-mimetic activity which acts independently of GABA receptors. In addition to its adaptogenic properties, ashwagandha may promote normal regulation of thyroid function. It has been shown to promote healthy serum levels of the thyroid hormones triodothyronine (T₃) and thyroxine (T₄), both of which are important in promoting normal metabolism.

Holy Basil: 375 mg
Holy basil has adaptogenic and calming activities. Research shows holy basil may help to promote normal plasma corticosterone levels, hepatic and renal functions, help maintain normal blood glucose levels, and inhibit several other stress related issues. Though the exact mechanism of action is not known, it is believed that much of holy basil's effect comes from its high content of eugenol, caryophyllene and triterpenoic acids, such as ursolic and oleanolic acids. Studies have shown eugenol to be effective promoting normal cyclooxygenase 2 (COX 2), an enzyme involved with the inflammatory response. 

L-Theanine: 200 mg
L-Theanine is an amino acid found in green tea and some mushrooms. Preliminary evidence suggests that l-theanine might induce subjective feelings of tranquility in healthy people. It is believed that l-theanine may work by promoting normal levels of the neurotransmitters GABA (Gamma Amino Butyric Acid) and dopamine in the central nervous system. GABA is the primary inhibitory neurotransmitter which promotes calming effects at the cellular level. Dopamine aids in the regulation of many functions within the brain in regards to behavior, cognition, sleep, mood, attention and memory, and is often associated with the ‘reward’ or ‘pleasure’ center of the brain.

Passion Flower Extract: 250 mg
Passion flower has sedative and relaxation effects. Some studies have pointed to the flavonoids in passion flower such as apigenin, vitexin, and isovitexin as the primary constituents responsible for its effects. Research suggests apigenin can bind to central benzodiazepine receptors in the brain, possibly causing relaxation and helping regulate mood without impairing memory or motor skills.

Bacopin^® (Bacopa monniera Leaf): 150 mg
Bacopa monniera, also referred to as brahmi, has a long history of use in Ayurvedic healthy for memory enhancement, support of learning and mood enhancement. Constituents of bacopa, specifically bacosides A and B have been shown to support learning ability, cognitive performance and improve mood. Bacopa also contains the flavonoids apigenin and luteolin. Research suggests apigenin can bind to central benzodiazepine receptors in the brain, possibly causing relaxation and helping regulate mood without impairing memory or motor skills.

Rhodiola rosea Root Extract: 50 mg
Rhodiola, or roseroot, acts as an antioxidant and adaptogen, promotes relaxation and mental clarity, and helps to improve mood. Research suggests that salidroside, one of over 30 compounds found in rhodiola, is responsible for its stimulating and adaptogenic effects. Within the brain, rhodiola appears to influence the level, activity and transport of monoamine neurotransmitters, such as dopamine, epinephrine and norepinephrine, and serotonin. Rhodiola has been proposed to promote healthy neurotransmitter levels.

Iodine: 150 mcg
The Atlantic kelp derived iodine in this formula has the most important function of promoting normal thyroid function and contributing to the body’s normal production of thyroid hormones. Iodine is absolutely crucial in maintaining optimal thyroid health.

Eleuthero Root (Eleutherococcus senticosus) Extract: 100 mg
Research has shown that eleuthero root, also known as “Siberian ginseng,” has antioxidant, adaptogenic, sedative, as well as many other effects. As an adaptogen it helps in promoting normal regulation of the endocrine system's response to stressors. The active compounds in eleuthero root, eleutherosides, are believed to stimulate the pituitary-adrenocortical system allowing for more efficient regulation of the stress response and healthy levels of cortisol. Other research suggests that it may help to support feelings of well-being, reduce occasional fatigue, and to improve memory and cognitive performance.

How should I take this product?
Take two per day. You may take one pill or both pills at the same time depending on your preference.

What other nutritional supplements could augment the biological effects of this product?
Isotonix^® B-Complex and Isotonix® Multivitamin

What are the contraindications for this supplement?
If you are currently taking warfarin (Coumadin), other anti-platelet/anti-coagulant medications, antihypertensive medications, anti-depressants, anti-anxiety medications or have an ongoing medical condition, you should consult your health care provider before using this product. If you have hyperthyroidism you should not take this product. Women who are pregnant or nursing should not use this product. This product may decrease the effects of stimulants and caffeine.

How does it promote relaxation without making you tired?
The Siberian Ginseng and the Ashwaganadha are natural stimulants. They reduce your stress levels but aren’t formulated to make you drowsy. Ginseng acts similar to caffeine but doesn’t make you jittery and won’t deplete your energy.

Can I take TLS® ACTS Adrenal, Cortisol, Thyroid and Stress Support Formula instead of my prescription?
No. TLS ACTS Adrenal, Cortisol, Thyroid and Stress Support Formula is not intended to replace any prescription medication. TLS ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula is a natural reliever of sudden stress. It is intended for use during or after engaging in stressful activities. You should contact your doctor before changing or discontinuing the use of any prescription medications.*

If I am on a prescription for anxiety, is it safe to use TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula?
You should consult your doctor before taking any dietary supplement. The ingredients in TLS ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula may have side effects, so make sure to contact your doctor before mixing them.

What is the relationship between Cortisol and the Thyroid?
Cortisol levels have a direct relationship with the thyroid and they act synergistically with one another. Cortisol assists the thyroid hormone in working more efficiently. The correct amount of cortisol – not too high or too low – supports normal thyroid function. When cortisol gets too high, triggered by the adrenal glands response to unwanted stress, it causes a delayed or absent response from the tissues to the thyroid hormone signal. This absent or delayed response from the tissues causes resistance from the thyroid hormone receptors. When cortisol gets too high, and this resistance occurs, it requires more hormones to create the same effect. That’s why elevated stress, which elevates cortisol levels, leads to a sluggish feeling. The hormones aren’t allowed to work at optimal levels. Every cell in the body has receptors for both cortisol and thyroid and nearly every cellular process requires an optimal functioning thyroid.*

How does TLS® ACTS Adrenal, Cortisol, Thyroid & Stress Support Formula support weight management?
When our bodies experience stress, we switch into "fight or flight" mode – our body’s response to perceived threat or danger. As a result, our bodies prepare to be sustained by building up "energy" (aka, fat) and strength for the battle. This response used to be beneficial to our ancestors, but now this response can be triggered in not so appropriate situations and repetitively. Stress can physically cause us to put on extra weight—and keep it there. Whenever we are under stress, our bodies release certain hormones by the adrenal gland—adrenalin and cortisol. Cortisol being the primary stress hormone. Cortisol is a potent signal to do two things—increase appetite and store fat. Increased cortisol in our body tells our brain that we're hungry, while at the same time telling our fat cells to store and hold onto as much fat as they can. TLS Adrenal, Cortisol, Thyroid and Stress Support Formula is a natural dietary supplement designed to help the body adapt to stress, promoting healthy levels of cortisol while enhancing and stabilizing mood, and supporting thyroid function.

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• Gohil KJ, Patel JA. A review on Bacopa monniera: Current research and future prospects. International Journal of Green Pharmacy. 4(1):1-9, 2010.
• Khanum, F., et al. Rhodiola rosea : a versatile adaptogen. Comprehensive Reviews in Food Science and Food Safety. 4:55-62, 2005.
• Panda, S. and Kar, A. Changes in thyroid hormone concentration after administration of ashwagandha root extract to adult male mice. Journal of Pharmacy and Pharmacology. 50(9): 1065-1068, 1998